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Throughout the years, valued members of the scientific community have contributed to the resonance of Espansione technologies such as Light Modulation® LLLT and Optimal Power Energy® IPL by publishing a vast array of research and scientific, peer-reviewed papers.

  1. D'SOUZA, Sharon, et al. Clinical and Molecular Outcomes After Combined Intense Pulsed Light Therapy With Low-Level Light Therapy in Recalcitrant Evaporative Dry Eye Disease With Meibomian Gland Dysfunction. Cornea, 2021.
  2. GIANNACCARE, Giuseppe, et al. Low-Level Light Therapy Versus Intense Pulsed Light for the Treatment of Meibomian Gland Dysfunction: Preliminary Results From a Prospective Randomized Comparative Study. Cornea, 2022.
  3. SOLOMOS, Leonidas, et al. Meibomian Gland Dysfunction: Intense Pulsed Light Therapy in Combination with Low-Level Light Therapy as Rescue Treatment. Medicina, 2021, 57.6: 619.
  4. STONECIPHER, Karl; POTVIN, Richard. Low level light therapy for the treatment of recalcitrant chalazia: a sample case summary. Clinical Ophthalmology (Auckland, NZ), 2019, 13: 1727.
  5. STONECIPHER, Karl, et al. Combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction. Clinical Ophthalmology (Auckland, NZ), 2019, 13: 993.
  6. DI MARINO, Matteo, et al. Combined Low-Level Light Therapy and Intense Pulsed Light Therapy for the Treatment of Dry Eye in Patients with Sjögren’s Syndrome. Journal of ophthalmology, 2021, 2021.
  7. MARTA, Ana, et al. Intense Pulsed Plus Low-Level Light Therapy in Meibomian Gland Dysfunction. Clinical Ophthalmology (Auckland, NZ), 2021, 15: 2803.
  8. PÉREZ-SILGUERO, Miguel Angel, et al. Combined Intense Pulsed Light and Low-Level Light Therapy for the Treatment of Dry Eye: A Retrospective Before–After Study with One-Year Follow-Up. Clinical Ophthalmology (Auckland, NZ), 2021, 15: 2133.
  9. PULT, Heiko; WOLFFSOHN, James S. The development and evaluation of the new Ocular Surface Disease Index-6. The Ocular Surface, 2019, 17.4: 817-821.
  10. PULT, Heiko. Low-level light therapy in the treatment of meibomian gland dysfunction. Investigative Ophthalmology & Visual Science, 2020, 61.7: 99-99.
  11. EL SHAMI, M., et al. Optimized combined low level light therapy and intense pulsed light therapy for the treatment of dry eye syndrome caused by Meibomian glands dysfunction. Journal Français d'Ophtalmologie, 2022.
  12. BORGIA, Alfredo, et al. Device-based therapies as a boost of conventional treatment in dry eye disease. Expert Review of Ophthalmology, 2022, just-accepted.
  13. RIVERA, José Y. Arteaga, et al. Combined Intense Pulsed Light and Low Level Light Therapy Vs. Oral Azithromycin for the treatment of moderate to severe hypersecretory meibomian gland disfunction. Investigative Ophthalmology & Visual Science, 2022, 63.7: 1966–A0296-1966–A0296.
  14. GIANNACCARE, Giuseppe et al. “Serial Sessions of a Novel Low-Level Light Therapy Device for Home Treatment of Dry Eye Disease.” Ophthalmology and therapy, 10.1007/s40123-022-00619-3. 9 Dec. 2022, doi:10.1007/s40123-022-00619-3

A number of other scientific articles, on numerous journals, have been published on Espansione technology.

  1. STONECIPHER, Karl, et al. Dry-eye Management Before Surgery, Review Of Ophthalmology, 2018.
  2. STONECIPHER, Karl, et al. Low-Level Light Therapy LLLT as an Adjunct Treatment For Meibomian Glands Dysfunction (MGD), Acta Scientific Ophthalmology, 2020.
  3. STONECIPHER, Karl; MATOSSIAN, Cynthia. What’s Meibomian Gland Disease Got in Store for the Future?, Ophthalmology Management, 2020.
  4. STONECIPHER, Karl. Low-Level Light Therapy, CRSTEurope, June 2021.
  5. STONECIPHER, Karl, et al. Current treatments for Meibomian Gland Dysfunction and Eye Lid Margin Disease, Acta Scientific Ophthalmology, 2021.
  6. CRAIG, Thomas. Understanding Photobiomodulation Therapy, Modern Optometry, 2021.
  7. ARZEL, Florian. Treatment of meibomian dysfunction by pulsed light and photo-biomodulation, Les Chaiers, 2021.
  8. FARRANT, Sarah. Eye-Light Intense Pulsed Light and Low-Level Light Therapy Fantastic, Optician Online, 2021.
  9. FARRANT, Sarah. Case Reviews in Dry Eye Management, Optician Clinical, 2021.
  10. KENIA, Vishal, et al. Effectiveness of eye-light therapy in improving dry eye symptoms, Indian Journal of Clinical and Experimental Ophthalmology, 2021.
  11. AMBROZIAK, Anna, et al. Blue Light Mask in Meibomian Glands Dysfunction with Demodicosis, Warsaw Ophthalmology Clinic, 2020.
  12. AMBROZIAK, Anna, et al. Combined Intense Pulsed Light and Low-Level Light Therapy for the Treatment of Ocular Surface Diseases (OSD): 2 Years Eye-Light Experience, Warsaw Ophthalmology Clinic, 2020.
  13. AMBROZIAK, Anna. New Treatments of Dry Eye Syndrome, Optyka, 2019.
  14. KARPECKI, Paul. Shed Some Light on Dry Eye Disease (DED), Review of Optometry, 2019.
  15. PULT, Heiko. Skin Temperature Measurement After Intense Pulsed Light and Application, Kontaktlinse, 2020.
  16. BURATTO, Lucio. Dry Eye in Patients with Clinical History of Blepharitis and Chalaziosis, Eye Doctor, 2018.
  17. MARINI, Leonardo, et al. Using LED Photobiomodulation to Treat Premature Ageing. Prime Journal, 2013.
  18. KARPECKI, Paul. Light Therapy Which Is Better, Review of Optometry, 2021.

Finally, a non-comprehensive overview of cross-referenced scientific papers featuring Intense Power Light (IPL) and Low-Level Light Therapy (LLLT).

  1. VORA, Gargi K.; GUPTA, Preeya K. Intense pulsed light therapy for the treatment of evaporative dry eye disease. Current opinion in ophthalmology, 2015, 26.4: 314-318.
  2. CRAIG, Jennifer P.; CHEN, Yen-Heng; TURNBULL, Philip RK. Prospective trial of intense pulsed light for the treatment of meibomian gland dysfunction. Investigative ophthalmology & visual science, 2015, 56.3: 1965-1970.
  3. TOYOS, Rolando; MCGILL, William; BRISCOE, Dustin. Intense pulsed light treatment for dry eye disease due to meibomian gland dysfunction; a 3-year retrospective study. Photomedicine and laser surgery, 2015, 33.1: 41-46.
  4. SANTANA-BLANK, Luis, et al. “Quantum leap” in photobiomodulation therapy ushers in a new generation of light-based treatments for cancer and other complex diseases: perspective and mini-review. Photomedicine and laser surgery, 2016, 34.3: 93-101.
  5. AVCI, Pinar, et al. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. In: Seminars in cutaneous medicine and surgery. NIH Public Access, 2013. p. 41.
  6. MORI, Asako, et al. Disposable eyelid-warming device for the treatment of meibomian gland dysfunction. Japanese journal of ophthalmology, 2003, 47.6: 578-586.
  7. OHSHIRO, Toshio, et al. The possibility of the application of low reactive level laser therapy in the field of ophthalmology. Laser Therapy, 2007, 16.4: 189-197.
  8. KOEV, K. Aplication of low-level laser therapy (LLLT) in patients with Retinitis Pigmentosa (RP). Acta Ophthalmologica, 2015, 93.
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